Category Archives: Medicine

Sildenafil

Sildenafil (other uncommon names: 1-[4-ethoxy-3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)phenylsulfonyl]-4-methylpiperazine, or C22H30N6O4S) is a common prescription drug originally synthesized by a group at the Pfizer’s facility in Sandwich, Kent, UK for use as a hypertension and heart disease drug, however, clinical trials found little impact on heart disease. It does however work well for treatment of a specific type of hypertension called pulmonary hypertension as well as altitude sickness, which may be experienced by mountain climbers and pilots, and another disorder. Some rare but serious side effects of sildenafil include stroke, heart attack, hypotension, and sudden hearing loss. Although illegal to use without a prescription, there is recreational use of sildenafil which is not diminished by the drug’s brand name and notoriety. Finally, the 2007 Ig Nobel Prize (not to be confused with the Nobel Prize) in Aviation went to an Argentinian team who discovered that sildenafil positively impacted how quickly hamsters recover from jet lag. Bonus points if you can guess the brand name of sildenafil (no cheating).

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